CVE-2024-50636

Severity: critical (CVSS 9.8 v3.1)
Exploited in the wild: not listed in CISA KEV
EPSS: 1.2% probability of exploitation in the next 30 days
Public exploit or detection template: none known
Published: 2024-11-11 · updated 2026-06-17
Weakness: CWE-94

Description

PyMOL 2.5.0 contains a vulnerability in its "Run Script" function, which allows the execution of arbitrary Python code embedded within .PYM files. Attackers can craft a malicious .PYM file containing a Python reverse shell payload and exploit the function to achieve Remote Command Execution (RCE). This vulnerability arises because PyMOL treats .PYM files as Python scripts without properly validating or restricting the commands within the script, enabling attackers to run unauthorized commands in the context of the user running the application.

Affected products

Schrodinger Pymol: 2.5.0

References

https://github.com/schrodinger/pymol-open-source/issues/405
https://github.com/yamerooo123/CVE/blob/main/CVE-2024-50636/Description.md
https://youtu.be/SWnN_a1tUNc

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