CVE-2025-12921: OpenClinica Community Edition CRF Data Import ImportCRFData xml injection

Severity: high (CVSS 8.8 v3.1)
Exploited in the wild: not listed in CISA KEV
EPSS: 0.6% probability of exploitation in the next 30 days
Public exploit or detection template: yes
Published: 2025-11-10 · updated 2026-10-07
Weakness: CWE-74

Description

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

Affected products

OpenClinica: 3.12.2, 3.13

References

https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#poc
https://vuldb.com/?ctiid.331641
https://vuldb.com/?id.331641
https://vuldb.com/?submit.680872
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md
https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#poc

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