CVE-2026-100843: MONAI before 1.6.0 Remote Code Execution via algo_from_pickle

Severity: high (CVSS 7.8 v3.1)
Exploited in the wild: not listed in CISA KEV
EPSS: 0.3% probability of exploitation in the next 30 days
Public exploit or detection template: yes
Published: 2026-09-27 · updated 2026-09-30
Weakness: CWE-502

Description

MONAI versions before 1.6.0 contain a remote code execution vulnerability in the algo_from_pickle() function due to unsafe pickle.loads() deserialization in monai/auto3dseg/utils.py. Attackers can craft malicious pickle files that execute arbitrary system commands when deserialized by the vulnerable function.

Affected products

Project-MONAI MONAI: before 1.6.0 — fixed in 1.6.0

How to fix

Upgrade to a fixed version: Project-MONAI MONAI 1.6.0. Check the vendor advisory for mitigations.

References

https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-qxq5-qhx6-94qw
https://www.vulncheck.com/advisories/monai-before-1.6.0-remote-code-execution-via-algo-from-pickle
https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-qxq5-qhx6-94qw

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